U.S. DOD/CDMRP: Amyotrophic Lateral Sclerosis Research Program (ALSRP) – Pre-proposals

Pilot Clinical Trial Award:

Applications must address one focus area: • Biomarker-Driven Interventions: Disease-modifying interventions, with mechanism-specific biomarkers to predict which clinical trial participants are likely to respond, demonstrate target engagement, and effects on the intended biological pathway. • Clinical Care: Improving aspects of clinical care and symptom management for ALS.

Funding: up to $2M for 3 years

Clinical Outcomes and Biomarkers Award: Supports the development and/or validation of clinical outcomes and/or biomarkers to enrich clinical trials in ALS.

Funding: up to $750K for 3 years

Therapeutic Development Award: Supports research ranging from preclinical validation of therapeutic leads through Food and Drug Administration Investigational New Drug (IND)- enabling studies

Funding: up to $1.5M for 3 year

Therapeutic Idea Award:

Supports new, innovative, high-risk, high-gain ideas aimed at ALS drug or therapy discovery. The studies supported by this award mechanism are expected to be hypothesis-driven and generate preliminary data for future avenues of therapeutic investigation.

Funding: to $600K for 2 years

https://ebrap.org/eBRAP/public/Program.htm

https://ebrap.org/eBRAP/public/ProgramFY.htm?programFYId=663102