Prostate Cancer Foundation: 2025 PCF TACTICAL Awards – Targeting Mechanisms of Lethal Prostate Cancer (LOI)

Support large-scale research projects concerning metastatic, lethal prostate cancer. PCF seeks high-risk, currently unfunded projects.
Research proposals in the following topic areas are solicited:
• Theranostics.
• Drugging currently undruggable oncology targets: preventing progression to lethal disease.
• Improved biotechnologies for precision medicine.
• First-in-field immunotherapies for prostate cancer.
• Artificial intelligence/machine learning to better inform patient outcomes.
• Host microbiome and tumor metabolism
Teams of at least 5 investigators from minimum 4 non-profit academic research institutions, Including 2 young investigators as integral
contributors. Cross-disciplinary teams that are diverse and inclusive will be favored.
Funding: $5 – $10M per award over 3–5 years
https://www.pcf.org/science-impact/for-researchers/open-rfas/
https://www.trdf.co.il/files/2025-TACTICAL-Award-RFA_4-8-25.pdf
https://www.trdf.co.il/files/LOI_Form_2025-TACTICAL_Awards.pdf