MAST Genes Research Foundation: 2026 MAST Genes Pilot Grant Program – LOI

The Program will support two investigator-initiated research projects aimed at advancing the biological understanding of the MAST genes and/or accelerating the discovery or development of therapeutic approaches.  Proposed projects must be directly relevant to the biology and clinical manifestations of MAST1, MAST2, MAST3, and/or MAST4 related neurodevelopmental disorders, and must align with at least one of the priority areas below:

1. Disease mechanisms and variant-level biology – Studies that advance understanding of how pathogenic or likely pathogenic variants in MAST1-4 alter protein expression, kinase activity, downstream signaling, or neuronal phenotypes…
2. Therapeutic approaches – Exploratory or proof-of-concept studies aimed at therapeutic discovery and target validation for MAST1 and MAST3 related disorders…
3. Multi-Investigator and Interdisciplinary Collaboration

Funding: $50,000 over 12 months.

https://orphandiseasecenter.squarespace.com/grants/mastgenesloi