Advanced Research Projects Agency for Health (ARPA-H): BIOGAMI BIOmolecular Grammar for protein Aggregation Modulation and Intervention – Solution Summaries

The BIOGAMI program aims to stop diseases like Alzheimer’s and other brain disorders by finding and fixing problems with proteins very early—before they clump together and damage cells. The program has two technical focus areas: (1) build next-generation artificial intelligence and experimental models for intrinsically disordered proteins (IDPs) and aggregation; and (2) leverage novel tools to develop novel therapeutic modalities that interfere with or prevent IDP misfolding and aggregation while preserving critical functions, and create novel detection capabilities that respond to early-stage IDP aggregation.

Please note: The BIOGAMI program is seeking unique multi-party teaming arrangements that enable teams to perform dynamically by bringing together the diverse expertise required for the program’s varying phases and aspects. Unlike a traditional prime/subperformer arrangement where the prime performer is the leader of the team throughout the program, the multi-party teaming structure allows different members of the team to take the lead role at different stages of the program life cycle based on expertise and experience.

https://arpa-h.gov/explore-funding/programs/biogami

https://sam.gov/workspace/contract/opp/23802b14ac3d4c79bd67c6cac7e06db5/view